Why are tricyclic antidepressants considered unsafe?

They are not unsafe. Tricyclic antidepressants are still used. However, they typically have a lot of uncomfortable side effects and because of this other antidepressants are preferred.

Related Questions

What are the differences between tricyclic antidepressants and snris?

Neurotransmitters. Tricyclic antidepressants are probably the most effective antidepressants we have. They affect a number of neurotransmitters and multiple circuits in the brain, alleviating depression, anxiety, migraines, and various pain syndromes. The down side to them is side effects and potential for stopping the heart in overdose. The serotonin-norepinephrine antidepressants are much safer. Read more...

Could a specialist please explain tricyclic antidepressants to me?

TCAs replaced . Tricyclic agents (TCAs) are used primarily as antidepressants. The TCAs were first discovered in the early 1950s and were introduced later in the decade;[ In recent times, the TCAs have been largely replaced in clinical use by the newer antidepressants which have more favorable side-effects profiles. TCAs neg. effects are-- cognitive dully, danger if overdosed, wt. gain, CVS & antichol. effects. Read more...

Why do tricyclic antidepressants prevent migraines?

Serotonin modulation. An excellent question. Amitriptyline affects multiple neurotransmitters, and it is believed that its modulation of serotonin calms the nerves that stimulate migraines. Read more...

Will tricyclic antidepressants cause man boobs?

Rarely. There have been rare reports of gynecomastia with tcas; i can not think of a clear cut case in the patients I have treated however. Read more...