Accutane & Acne. Accutane (isotretinoin) is far and away the best medication for stubborn acne. Many cautions when taking it, though. If you are female, you have to have monthly pregnancy tests to make sure you are not pregnant while you are taking it. If you are a male, it's much easier to get. The high price of the drug puts many people off. A dermatologist can explain it all to you if you are a good candidate.
Yes but. It usually is extremely effective, but side effects range from the annoying dryness of lips and skin that you will surely experience to (some say) real depression. You absolutely must not take it if there is the least chance you are going to get pregnant. If you are not satisfied with, say, the results of topical clindamycin, it's between you and your physician.