I am currently on warfarin, 81 mg baby aspirin, and metoprolol after two open heart surgeries. I have a horrible sore throat/cold. What can I take?

Tylenol (acetaminophen) for pain and. Amoxicillin for infection. Maybe cloroseptic lozenges will help. All the best.
Topical is best. To avoid anything which might interact with warfarin - stick to products that act locally and/or very minimally absorbed (systemically). Start an antibiotic. For a sore throat, I'd suggest the Chloraseptic Max throat lozenges ... They work quite well and are fairly potent. For the runny nose/cold - try an intranasal spray like Flonase or Nasonex (mometasone). See your MD. Hope that helps!