Is spina bifida hereditary?

Studies show that . the incidence of neural tube defects (NTD's) like open Spina Bifida would decrease by 70% if all women took 0.4mg of Folic Acid daily from menarche to menopause. However, this dose does not prevent NTD's in offspring of women with variations in several genes involved in folate (folic acid) & homocysteine metabolism. There are also inheritable genetic causes of NTD's that are not related to folate (folic acid) metabolism. .

Related Questions

What type of inheritance is involved in spina bifida?

Multifactorial. Isolated spina bifida (myelomeningocele) is a neural tube defect along with anencephaly that exhibits multifactorial determination--a combination of many genes and in utero environmental factors that cross a threshold to produce the defect. A couple having a child with spina bifida or anencephaly has a ~2% risk for each future pregnancy, a risk decreased by preconception folic acid. Read more...
Dominant or not. Some hereditary forms are dominant, meaning only one parent needs to be affected to pass the condition to offspring. Other forms are recessive, meaning both parents have to contribute defective genetic material. Some genetic defects require a little "help" from factors such as maternal Folic Acid deficiency or "teratogenic" drugs. Consult obstetrician about medication usage, including otc ones. Read more...

Is occult spina bifida inherited? Mom and I both have dimple on lower back. Mine shows up on xray.

Spina Bifida Occulta. There is genetic basis for the disorder, but most likely interaction of multiple genes as well as environmental factors such as Folic Acid deficiency in the pregnant mother. If mother had 1 child with sbo, there is 3% chance that her second child will have sbo. This risk can be reduced to 1% if mother takes high dose Folic Acid at 4mg. Daily, before & during pregnancy. Read more...

What is spina bifida?

Spinal cord disorder. The spinal cord forms as an open tube that starts to close from the middle out to the two ends. The entire closure is done by about ten weeks. If the closure is not normal than a condition known as spina bifida occurs. Open spina bifida is when there is an opening in the spinal column to the skin. Closed spina bifida is when there is an opening in the spinal column but it has a thin cover. Read more...
Lack of closure. In the fetus the spine develops with two parts that come together. The spinal cord is a flat strip that folds up and closes. If these two parts do not fold up and close, they leave an opening in the spine with the spinal cord hanging loose. This appears as a sack usually at the base of the spine. The nerves to the legs, bowels and bladder are often involved. The sack needs to be closed. Read more...
Different forms. There are several types of spina bifida. All of them are the result of abnormal neural formation. Some types have some bone missing and other types have the neural sac exposed and others have the nerves exposed. Maintaining appropriate levels of folate (folic acid) prior to being pregnant is important as low levels have been correlated with higher incidence. Hope this helps. Read more...

What is spina bifida?

Spina Bifida. Spina bifida is a birth defect where the spine does not close around the spinal cord during development. This may be as small as a small gap between the 2 sides, with no buldging out of membranes or nerves, & no associated handicaps, to a large defect with part of the cord exposed outside the body, leading to paralysis and other neurological problems. Folic acid decreases the risk. Read more...
Spina bifida. Is a congenital malformation of the vertebra, at any level, though usually the lumbar, which lays the spinal cord open to the air. It usually leads to paralysis of the lower limbs, bladder and bowel and a strong chance of meningitis. Read more...

Who discovered spina bifida?

Although depictions . of people with Spina Bifida go back 12,000 years, Amsterdam's Dr. Nicholas Tulp named the disorder between 1618-1652. Dr. Giovanni Battista Morgagni an Italian, linked lower-limb deformity & hydrocephalus to Spina Bifida in 1761. Studies show that the incidence of NTD's could decrease by as much as 70% if all women were to take a daily Folic Acid supplement from menarche to menopause. . Read more...

Do you deal with spina bifida?

A life-long story. Spina bifida prevention begins before pregnancy, with folate (folic acid) supplements. Tests are done in pregnancy to prevent spina bifida newborns. If born with it, a child enrolls in a spina bifida clinic at a childrens' hospital. The child needs help with peeing & pooping, mobility (braces, wheelchairs), and with integrating into regular schools. His life will be like that of someone paralyzed in both legs. Read more...
Spina Bifida(myelome. It is a birth defect in which the back bone and spinal canal do not close before birth and babies are born with sac sticking out of the middle and low back the defect has to be closed after birth but it may not restore normal function , intrauterine surgery for spina bifida has been performed by some.Incidence can be redoced 70% by Folic Acid prenatal it may be associated woth hydro/anen cephaly. Read more...
Yes. Yes, but rarely. This condition is not common and as a family physician, i see only what comes my way. Spina bifida is usually approached in a team concept, usualy dealing with a primary care doctor (pediatrician, family physician or internest) along with physical therapist, neurologists, neuro-surgeons, physiatrist (physical medicine specialists) and a host of others. There are many issues. Read more...
Yes, if GU problem/s. Spina bifida simply means that bony encasement of spinal canal is incomplete. Most cases are spina bifida occulta, do not have nerve or spinal cord involvement & require no treatment. I deal with patients who have involvement of underlying spinal cord & spinal nerves (myelocele) or both spinal cord coverings (meningocele) plus meningocele (myelomeningocele) having bladder & incontinence problems. Read more...
Spina bifida. Yes we do deal with spina bifida with a large multidisciplinary team that deals with all the various manifestations of this disorder including neurological, orthopedic, urological, therapy among other specialists. Read more...

What are the signs of spina bifida?

Spina Bifida. Depends on the type; 1. Spina bifida occulta shows small gap in 1 or more of spinal bones, seen in newborn as a small dimple or birth mark or tuft of hair or fat collection. 2. Meningocele shows as bulging of meninges (sheath around spinal cord) through the opening in back. 3. Myelomeningocele is wider protrusion through several vertebrae, forming a large sac. This is most severe. Read more...

What are the tests for spina bifida?

Spina bifida. Spina bifida is usually diagnosed by x-ray for MRI of the lower spine. In the new born it can also be done with an ultrasound. Read more...
Depends . There are three forms. Spina bifida occulta is the mildest and may go indiagnosed throughout life. The other two can be diagnosed on exam and with radiographs upon birth or intrauterine (meningocele and myelomeningocele). It can be diagnosed while child still in gestation via certain blood test and confirmed with ultrasound. Decrease incidence by taking enough Folic Acid before and during preg. Read more...
Spina bifida occulta. If you are meaning spina bifida occulta, the main test are x-rays. If there is a question of complications such as a tethered spinal cord, MRI would be the test of choice. Read more...

Can you tell me what spina bifida means?

Split spine. Spina bifida is a generic term used to describe congenital malformations of the spine (typically lower spine). It can be mild to very severe and be associated with a variety of conditions. Read more...