How easily can the body handle niacin?

Reasonably well. Niacin usually causes vasodilation, causing feelings of hot flushes. Usually recommended to be taken at night with aspirin 30minutes early. Usually this allows the individual to tolerate Niacin better Cheers! C.
Niacin. Supplementing with 2000-3000mg of flush free Niacin daily can help to control your cholesterol levels quite nicely, even increasing your HDL and converting your LDL to a less harmful subtype. As a negative, Niacin can cause facial flushing and redness so get the flush free variety. And have your liver enzyme values monitored, as they can be affected by Niacin use.