Is folfiri alone effective for metastic colon cancer than irinotecan alone?

Two drugs vs one dru. Folfiri contains two drugs in the combination: 5-FY(Folinic acid) and Irinotecan. This combination is more effective than using irinotecan alone. It is often combined with Avastin (bevacizumab) in case it is being used to treat colon cancer.

Related Questions

How effective is irinotecan alone for metastic colon cancer?

Work w/ your Dr. This is worth discussing w/ your Dr or getting a 2nd opinion. They spent years building a knowledge base and also have examined you! Some research finds it less beneficial alone than in combo: http://www.ncbi.nlm.nih.gov/pubmed/24560487 But talk about your case w/ your team. Read more...

Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed?

Yes. Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. Read more...

How effective is irinotecan alone for colon cancer when primary removed but there occured a liver met and a node?

Your Oncologist. And ONLY your oncologist ..should answer this question since PERCENTAGES are not PEOPLE! Good Luck Hope this helps! Dr Z. Read more...
Modestly active. Irinotecan is one of 3 chemotherapy drugs used for treating Cancer. They work better when used as a couplet or triplet, often with added biologic agent called Avastin (bevacizumab) and sometimes adding Cetuximab. Read more...

How effective is the FOLFIRI chemotherapy regimen for treating colon cancer?

Some effect. Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. Read more...

How effective is the FOLFIRI-Bevacizumab chemotherapy regimen for treating colon cancer?

Moderately useful. FOLFIRI-Bev is the standard, commonly used first line chemotherapy for metastatic Colon cancer. It can add about 12 to 18 months extra to your life such that an average patient can live for 2 to 3 years(some live upto 5-6 years... depending on sites of metastases and their response to chemotherapy. You need tell us more about your history such as dates of diagnosis and treatments/results so far?? Read more...

How effective are Irinotecan injections for treating colon cancer?

Pretty good. Usually they're part of a protocol. If I were offered this as adjuvant Rx and it was affordable from my end, I'd probably go ahead if it was offered by an ethical oncologist. I'd quit if it was clearly not helping. Read more...

If Xeloda (capecitabine) and irinotecan alone not worked in colon cancer Pt, that mean no chemotherapy will work?

Others may help. If certain chemos do not give the proper response, one can take a fresh bx and send it for chemosensitivity and cahemoresistant studies. This will tell which wont work and which have the potentail to help either as single agents or combinations of drugs including use of immune drugs including Avastin (bevacizumab) and Erbitux. Read more...

What option is there if chemo fails for met colon cancer? Xeloda (capecitabine) n irinotecan failed

Oxaliplatin is good. Another good chemo drug is Oxaliplatin. This is often used in combination with 5-FU and Avastin (bevacizumab). If your tumor is KRAS wild type, then EGFR inhibitors(like Cetuximab and Panitumumab) also become relevant choices to use alone or in combination with other drugs. Read more...