Buspirone or Buspar (buspirone) Buspirone needs to be taken regularly every 6-8 hours in an amount enough to reduce anxiety. It does not work prn because it needs to build a level in your nervous system to act appropriately. It is very effective taking up to 2-3 days to stabilize in your system. The usual doses are 10-20 mg three times a day with meals. It is a great alternative to sedatives, and also acts as a mood stabilizer.

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3 Doctors Approved

Dr. David Cohen, University of Delhi, University College of Medical Sciences and GTB Hospital Answered Mar. 30, 2013

40 years experience in Internal Medicine

No. No. For it to work you need to take it daily.

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Dr. Alan Ali, University of Arkansas for Medical Sciences/UAMS College of Medicine Answered May. 18, 2015

30 years experience in Psychiatry

Buspar (buspirone) PRN. Nope.