I have middle ear infection with slight discharge but no pain. I', given by ENT doc ofloxacin opth drops + cefpodoxime 200 tbs. Can I go ahead, start?

Why did you wait. If there was no reason to wait, it is safe to use Ofloxacin eye drops for the ear. If you are getting worse with a fever or other worsening symptoms, see your ENT before starting as a culture before starting antibiotics may help.
Yes . Assuming you r not allergic to any of the medications in question . I. Would advise that if you had reservations you should have discussed them openly with your doctor . Good luck. Jp.