Is it safe to take 2500mg tylenol (acetaminophen) daily long term? Is it also safe to take that long term during pregnancy?

Tylenol (acetaminophen) Toxicity. The simple answer to your question is no. Tylenol (acetaminophen) is very toxic in high and regular doses to your liver. I am not sure why you are taking this daily and would advise you to get to your obstetrician to make sure they are aware of this and to give them a chance to discuss healthier options for you.