Lemon balm and Effexor (venlafaxine) XR interactions?

Lemon balm & Effexor (venlafaxine) There are no direct interactions between the herb lemon balm and effexor, (venlafaxine) but lemon balm does have CNS depressant effects. That's how it may calm agitation, etc. I suggest caution and also discussing this possible use with your doctor. If Effexor (venlafaxine) is not providing the results you hope for, another reason for discussion.