Doe s taking Zoloft (sertraline) affect your sex drive? Is there anything that can help with this?

Yes. Zoloft (sertraline) can decrease sex drive. You should talk to your doctor to see if you ifanother medication might be beneficial without this side effect.
Zoloft (sertraline) Some physicians will prescribe periactin. This can be used before intercourse, but its not effective for everyone and may cause sedation. Your best bet might be switching to pristiq (desvenlafaxine). This is more expensive, but has much less sexual side efffects.