My nose itches when I take vicodin?

Histamine Release. What you are experiencing is not uncommon with opioids such as hydrocodone in vicodin, lortab and norco, codeine, morphine and similar meds.Certain patients do better with different drugs. A mild antihistamine like Phenergan (promethazine) can sometimes help with the itching and/or nausea which occur with opioids.
Histamine. Most likely a reaction due to histamine release. Have your doctor presribe a different medication for pain.