Least OTC as possibl. Over the counter medicines like non-steroidals e.g. Ibuprofen and Naproxen need to be used cautiously and after meals. Also, tylenol (acetaminophen) a few times daily on bad days could be used. However, if pain is worse or continuous you need to see your nephrologist since some of the large cysts could be aspirated yielding pain relief at least temporarily. The procedure is simple.
Tylenol (acetaminophen) Otc medications such as Acetaminophen (tylenol), Ibuprofen are effective for cyst pain. Do not take Ibuprofen more than twice a week as larger doses and long term use has been associated with kidney problems. If the pain persists then see your nephrologist as the cyst may be very large and may benefit from needle aspiration.