8 doctors weighed in:
How would I go about confirming a caffeine allergy/ intolerance? When I consume caffeine I have what seems to be an anaphylactic reaction.
8 doctors weighed in

Dr. Andrew Murphy
Internal Medicine - Allergy & Immunology
4 doctors agree
In brief: Distinctly Unusual
Caffeine allergy is unusual but has been reported in the literature.
After speaking to your allergist and clarifying your history, there are several options that could be explored. Skin testing could be done but there is no standardized skin test reagents for caffeine thus the results must be interpreted with care. Oral challenges could be considered but only with your physicians supervision.

In brief: Distinctly Unusual
Caffeine allergy is unusual but has been reported in the literature.
After speaking to your allergist and clarifying your history, there are several options that could be explored. Skin testing could be done but there is no standardized skin test reagents for caffeine thus the results must be interpreted with care. Oral challenges could be considered but only with your physicians supervision.
Dr. Andrew Murphy
Dr. Andrew Murphy
Thank
Dr. Steven Machtinger
Internal Medicine - Allergy & Immunology
3 doctors agree
In brief: Not likely
Caffeine is a small molecule that rarely, if ever, causes anaphylaxis.
Like any other possible allergen a skin test is performed. If history is convincing & test positive no further testing is required. Otherwise a blinded challenge is done in the office.

In brief: Not likely
Caffeine is a small molecule that rarely, if ever, causes anaphylaxis.
Like any other possible allergen a skin test is performed. If history is convincing & test positive no further testing is required. Otherwise a blinded challenge is done in the office.
Dr. Steven Machtinger
Dr. Steven Machtinger
Thank
2 comments
Dr. Jack Mutnick
Dr. Machtinger answered the question perfectly. Testing is difficult for foods, especially if consumed previously without a reaction. But a test could start with scratch testing, then blood work, then finally performing a food challenge either single or double-blinded in the office of a trained allergy specialist
Dr. Steven Machtinger
Good advice from your allergist.
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