My huabands neck has been hurting for a couple days at the base. Could this be from his pillow or something wrong?

Pain in neck. Neck pain can be due to sleeping on it wrong - as you suspect. Also, by propping your head with a pillow, these symptoms can be magnified. Occipital neuralgia is one cause. It is due to whiplash injury or neck arthritis. Certainly straining the muscles of neck due to heavy lifting or inordinate exertion could be responsible. If this persists, pursue thorough and careful neurological examination.
Could be pillow. Could be the pillow but could be something else. If you or he is concerned, see a doctor.