Prescribed fluconazole for vaginal yeast infection. Liver warnings scare me! How common is liver damage with one pill?

Very uncommon . The possibility of liver irritation is more for those who are on this medication chronically. It is safe to take to get rid of your yeast infection.
Rare Rare Rare. One single pill will most likely cause no liver trouble. Diflucan (fluconazole) is a very effective treatment for vaginal yeast infection for 2 reasons. Not only does it take care of the vaginal yeast overgrowth which causes terrible itching; it also kills off bowel yeast which may feed into future yeast infections. It is a very safe medication, and works very well for yeast infection.