4 doctors weighed in:

What is the vertical cholesterol profile test and what's its best use case?

4 doctors weighed in
Dr. Irv Loh
Internal Medicine - Cardiology
2 doctors agree

In brief: Limited

Not sure what you mean by "vertical", but if you mean the extended lipid profiles with particle size and density, i would say practical use is limited.
In my research work, extensive lipid profiles important, but clinically, very limited data suggesting that knowledge of the extra data actually changes treatment and outcomes. Question usually is to whether to add niacin; other ways to decide.

In brief: Limited

Not sure what you mean by "vertical", but if you mean the extended lipid profiles with particle size and density, i would say practical use is limited.
In my research work, extensive lipid profiles important, but clinically, very limited data suggesting that knowledge of the extra data actually changes treatment and outcomes. Question usually is to whether to add niacin; other ways to decide.
Dr. Irv Loh
Dr. Irv Loh
Thank
Dr. Stephen Sisselman
Internal Medicine

In brief: Particle size

Hello, the main difference between a "regular" cholesterol test and VAP is the VAP gives particle size.
It is thought that smaller more dense LDL is more atherogenic - will cause atherosclerosis more readily than larger more buoyant LDL. Even better are tests that give particle concentration, such as LDL-P. Atherosclerosis is concentration driven so the more particles of LDL the worse it is.

In brief: Particle size

Hello, the main difference between a "regular" cholesterol test and VAP is the VAP gives particle size.
It is thought that smaller more dense LDL is more atherogenic - will cause atherosclerosis more readily than larger more buoyant LDL. Even better are tests that give particle concentration, such as LDL-P. Atherosclerosis is concentration driven so the more particles of LDL the worse it is.
Dr. Stephen Sisselman
Dr. Stephen Sisselman
Thank
1 comment
Dr. Irv Loh
Just keep in mind that there are no interventions specifically based on particle size or density. If one believes in aggressive therapy, the therapy for any particular lipid abnormality is essentially the same. We assess particle size and density in essentially all of our lipid research projects, but clinical implications remain moot until some outcome trial based on particles shows superiority.
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