Will bupropion sr and delsym (dextromethorphan) night interact?

A valuable resource. You can use a drug interaction checker whenever you have questions about drug-drug interactions or drug - food interactions. Here is one option (Drugs.Com): https://www.drugs.com/drug_interactions.php Your pharmacist is also an excellent source of information.

Maybe (not) . . . Always ask your pharmacist & prescribing physician about drug interactions. They have the final say-so. Otoh, you can use online.Epocrates.Com & drugs.Com to search for drug-drug interactions. Epocrates says no (there are 2 kinds of delsym night time) while drugs.Com says there's moderate interaction btwn bupropion & dextromethorphan. So best to ask your pharmacist & family doc for final ruling.