How to get rid little white bumps on the upper lips? Some people call them Fordyce spots. Nothings works even tretinoin...

Consider Laser. I have had success with carbon dioxide laser resurfacing of the mucosa to improve the appearance of Fordyce spots.
Laser, electrosurger. These could be flattened with a co2 or erbium laser. This wil require a few days of healing. Since the depth of spots can vary you may bot be able to totally get rid of these, only improve the appearance.