9 doctors weighed in:

What are the direct dangers to the brain and effect of impairing glutamate, endorphine and GABA functioning with alcohol?

9 doctors weighed in
Dr. Jeff Blixt
Addiction Medicine
6 doctors agree

In brief: See Below

Chronic abuse of alcohol causes dysregulation of the neurotransmitters, the receptors that these neurotransmitters act on also change.
Alcohol is a depressant so the brain tries to balance itself out if chronically exposed, when alcohol is removed, brain cannot adjust back quickly, and is hyperexcited with excess glutamate, decreased gaba and endorphins, thus withdrawal and cravings begin.

In brief: See Below

Chronic abuse of alcohol causes dysregulation of the neurotransmitters, the receptors that these neurotransmitters act on also change.
Alcohol is a depressant so the brain tries to balance itself out if chronically exposed, when alcohol is removed, brain cannot adjust back quickly, and is hyperexcited with excess glutamate, decreased gaba and endorphins, thus withdrawal and cravings begin.
Dr. Jeff Blixt
Dr. Jeff Blixt
Thank
Dr. Alan Wartenberg
Addiction Medicine
1 doctor agrees

In brief: Physical damage

Alcohol ultimately results in increased brain glutamate, and this Amino Acid is neurotoxic and may be partly responsible for the brain damage, as well as the marked excitation, delirium, seizures and memory problems found in alcoholics.
The endorphin and gaba changes do not cause damage, but are part of the addictive cycle that alcoholics develop, wanting more gaba and endorphin effects.

In brief: Physical damage

Alcohol ultimately results in increased brain glutamate, and this Amino Acid is neurotoxic and may be partly responsible for the brain damage, as well as the marked excitation, delirium, seizures and memory problems found in alcoholics.
The endorphin and gaba changes do not cause damage, but are part of the addictive cycle that alcoholics develop, wanting more gaba and endorphin effects.
Dr. Alan Wartenberg
Dr. Alan Wartenberg
Thank
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