Lung infection prednisone my wife has bee n on prednisone for over a year now every time here prescription runs out she goes into breathing distress.

Respiratory Distress. It appears that your wife has a severe upper respiratory inflammation which is only suppressed by systemic administration of corticosteroids. Check with pulmonologist to see if some other form of anti-inflammatory therapy could be administered or at least added to her current steroid regimen.