6 doctors weighed in:

If an autoimmune disease is in remission at the time of ANA testing could the test be negative but possibly still have the disease. Eg RA or sle ?

6 doctors weighed in
Dr. Nayla Mumneh
Internal Medicine - Allergy & Immunology
3 doctors agree

In brief: Yes

The ANA fluctuates.

In brief: Yes

The ANA fluctuates.
Dr. Nayla Mumneh
Dr. Nayla Mumneh
Thank
1 comment
Dr. Sheeja Francis
ANA does not fluctuate with disease activity.
Dr. Ed Friedlander
Pathology
1 doctor agrees

In brief: Yes

The anti-nuclear antibody (ANA) titer fluctuates over time, and it's also a test fraught with pitfalls within the lab, with results hard to reproduce even from day to day.
I'm very glad you asked; this is a thoughtful and important question that touches on how tricky it is to manage these diseases. The key is treat the person, not the lab value.

In brief: Yes

The anti-nuclear antibody (ANA) titer fluctuates over time, and it's also a test fraught with pitfalls within the lab, with results hard to reproduce even from day to day.
I'm very glad you asked; this is a thoughtful and important question that touches on how tricky it is to manage these diseases. The key is treat the person, not the lab value.
Dr. Ed Friedlander
Dr. Ed Friedlander
Thank
1 comment
Dr. Sheeja Francis
ANA does not fluctuate based on disease activity. Approximately 15% of the normal population may have a positive ANA. All autoimmune diseases are diagnosed clinically and laboratory results are used as supporting tools.
Dr. Ronald Krauser
Internal Medicine - Rheumatology
1 doctor agrees

In brief: Yes

Autoantibody tests can sometimes become negative when the disease is in remission.
However, the high likelihood is that the underlying disease is still present.

In brief: Yes

Autoantibody tests can sometimes become negative when the disease is in remission.
However, the high likelihood is that the underlying disease is still present.
Dr. Ronald Krauser
Dr. Ronald Krauser
Thank
1 comment
Dr. Sheeja Francis
ANA does not change based on disease activity.
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