7 doctors weighed in:
Can one build a tolerance to imitrex (sumatriptan)? 
7 doctors weighed in

Dr. Julian Bragg
Neurology
4 doctors agree
In brief: In a way
There does seem to be a waxing and waning effect of many headache medications, and a drug that works well for years can become less effective with time.
In addition, using Imitrex (sumatriptan) more than 2-3 times per week can lead to the development of a medication overuse headache, which is very difficult to effectively treat. You may wish to consider adding a prophylactic medication.

In brief: In a way
There does seem to be a waxing and waning effect of many headache medications, and a drug that works well for years can become less effective with time.
In addition, using Imitrex (sumatriptan) more than 2-3 times per week can lead to the development of a medication overuse headache, which is very difficult to effectively treat. You may wish to consider adding a prophylactic medication.
Dr. Julian Bragg
Dr. Julian Bragg
Thank
Dr. William Howland
Internal Medicine - Allergy & Immunology
1 doctor agrees
In brief: Yes
If used frequently Triptan medicines like imitrex (sumatriptan) can become less effective.
In some cases rebound headaches can occur with analgesics like Advil as well as with Triptans. Migraines can be transformed into chronic daily headaches due to overuse of headache medicines.

In brief: Yes
If used frequently Triptan medicines like imitrex (sumatriptan) can become less effective.
In some cases rebound headaches can occur with analgesics like Advil as well as with Triptans. Migraines can be transformed into chronic daily headaches due to overuse of headache medicines.
Dr. William Howland
Dr. William Howland
Thank
In brief: Not uncommon
This is but one reason we have so many triptans, as response is very variable, tolerance does develop and some patients do NOT even respond, making it necessary to try alternative abortives such as ergotamines or Cambia.

In brief: Not uncommon
This is but one reason we have so many triptans, as response is very variable, tolerance does develop and some patients do NOT even respond, making it necessary to try alternative abortives such as ergotamines or Cambia.
Dr. Bennett Machanic
Dr. Bennett Machanic
Thank
Get help from a real doctor now
Dr. Bennett Machanic
Board Certified, Neurology
48 years in practice
55M people helped
Continue
107,000 doctors available
Read more answers from doctors