5 doctors weighed in:

Vyvanse (lisdexamfetamine) states it's not effected by food since it's broken down in the small intestine. Is it's efficacy changed by urine pH or frequent urination?

5 doctors weighed in
Dr. Edward Kuhnley
Pediatrics - Psychiatry
2 doctors agree

In brief: Efficacy is not

Affected but excretion of amphetamine is after covalent bond between Dextroamphetamine and l-lysine is broken.
The percent of dose excreted as unchanged drug varies greatly depending upon urinary ph & urine flow. At low ph as much as 70% of the dose may be excreted as amphetamine in 24 h, whereas as little as 1% may be excreted within 24 h at alkaline ph (j. Pharm. Pharmacol. 21:241-258 (1969).

In brief: Efficacy is not

Affected but excretion of amphetamine is after covalent bond between Dextroamphetamine and l-lysine is broken.
The percent of dose excreted as unchanged drug varies greatly depending upon urinary ph & urine flow. At low ph as much as 70% of the dose may be excreted as amphetamine in 24 h, whereas as little as 1% may be excreted within 24 h at alkaline ph (j. Pharm. Pharmacol. 21:241-258 (1969).
Dr. Edward Kuhnley
Dr. Edward Kuhnley
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Dr. Samuel Miles
Psychiatry
2 doctors agree

In brief: No

Urine ph or frequency will not effect efficacy of vyvanse (lisdexamfetamine).

In brief: No

Urine ph or frequency will not effect efficacy of vyvanse (lisdexamfetamine).
Dr. Samuel Miles
Dr. Samuel Miles
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