10 doctors weighed in:
How does alcohol interfere with the mechanism of anti depressants and mood stabilizers?
10 doctors weighed in

Dr. Neil Liebowitz
Psychiatry
5 doctors agree
In brief: Alcohol depletes 5ht
Alcohol causes whatever serotonin is available in the brain to be released.
This is why you feel good initially. Antidepressants help the brain better utilize what serotonin exists, so after drinking you have basically depleted all the serotonin and can get acutely depressed. It can take up to a week to replenish the serotonin after one episode of drinking (only 4 or more drinks).

In brief: Alcohol depletes 5ht
Alcohol causes whatever serotonin is available in the brain to be released.
This is why you feel good initially. Antidepressants help the brain better utilize what serotonin exists, so after drinking you have basically depleted all the serotonin and can get acutely depressed. It can take up to a week to replenish the serotonin after one episode of drinking (only 4 or more drinks).
Dr. Neil Liebowitz
Dr. Neil Liebowitz
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Dr. Arman Danielyan
Pediatrics - Psychiatry
2 doctors agree
In brief: Alcohol depression
In addition, alcohol by itself is a central nervous system depressant.

In brief: Alcohol depression
In addition, alcohol by itself is a central nervous system depressant.
Dr. Arman Danielyan
Dr. Arman Danielyan
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1 comment
Dr. Kevin Nasky
Central nervous system depressant, of course, doesn't mean that the agent will cause depressed mood. Benzodiazepines are CNS depressants (with a GABA-ergic mechanism similar to alcohol), and those aren't thought to cause or worsen depression (and often successfully prescribed in patients with comorbid anxiety and depression). Further, there is no evidence that alcohol effects the efficacy of ADs.
Dr. Stuart Wasser
Addiction Medicine
1 doctor agrees
In brief: See below
Alcohol affects glutamate, endorphine and gaba function.
All these neurotransmitters impact anti depressants and mood stabilizers function.

In brief: See below
Alcohol affects glutamate, endorphine and gaba function.
All these neurotransmitters impact anti depressants and mood stabilizers function.
Dr. Stuart Wasser
Dr. Stuart Wasser
Thank
1 comment
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