My lialda ran out and I am getting worse ulcerative colitis at 20mg prednisone a day. My lialda will come in a couple days. Should I take 40 mg pred?

Call doctor. Call your doctor in the morning. Let him or her know you are out of lialda. This is a once a day medicine. Try to not run out in the future by having a week or two ahead at all times. But you are not alone. Many patients run out of medicines and this is called compliance. Work with your doctor to get the best schedule rather than taking extra of what you do have.