Sle = systemic lupus erythematosis.
This is a complex disease. It is an "auto-immune" disease, which means that many symptoms are due to the production of antibodies that attack the sufferer's own body. Symptoms can include fevers, aches/pains, fatigue, weight loss, kidney disease, rash
, easy clotting, many others. Treatment includes suppressing the immune system to reduce the antibodies.