6 doctors weighed in:
How is Neurontin (gabapentin) processed in the body and what are the side effects?
6 doctors weighed in

Dr. Einar Ottestad
Pain Management
4 doctors agree
In brief: Min
Gabapentin is extremely safe.
It is not metabolized by the lover and is excreted unchanged by the kidney. It is also actively absorbed in the small intestine so if you drank a gallon of it, most would not even be absorbed, just pooped out. No liver/kidney/heart/stomach toxicity. Doesnt interact with other meds. Se are mainly sedation unless titrated slowly, weight gain, and swelling.

In brief: Min
Gabapentin is extremely safe.
It is not metabolized by the lover and is excreted unchanged by the kidney. It is also actively absorbed in the small intestine so if you drank a gallon of it, most would not even be absorbed, just pooped out. No liver/kidney/heart/stomach toxicity. Doesnt interact with other meds. Se are mainly sedation unless titrated slowly, weight gain, and swelling.
Dr. Einar Ottestad
Dr. Einar Ottestad
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Dr. Paul Reynolds
Pain Management
1 doctor agrees
In brief: Kidney
Sleepiness and confusion are common complaints.
Some complain of weight gain. There are reports of depression. Most find it helpful. Keeping the dose low tends to lessen side effects.

In brief: Kidney
Sleepiness and confusion are common complaints.
Some complain of weight gain. There are reports of depression. Most find it helpful. Keeping the dose low tends to lessen side effects.
Dr. Paul Reynolds
Dr. Paul Reynolds
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Dr. David Rosenfeld
Pain Management
In brief: Pretty simple
Neurontin (gabapentin) is not metabolized.
It is eliminated by the kidneys. Because the elimination of Neurontin (gabapentin) is entirely renal, patients with renal insufficiency usually need lower dosages and less frequent dosing. Side effects of Neurontin (gabapentin) are generally mild to moderate and transient. The most commonly reported dose-related side effects are: drowsiness dizziness fatigue.

In brief: Pretty simple
Neurontin (gabapentin) is not metabolized.
It is eliminated by the kidneys. Because the elimination of Neurontin (gabapentin) is entirely renal, patients with renal insufficiency usually need lower dosages and less frequent dosing. Side effects of Neurontin (gabapentin) are generally mild to moderate and transient. The most commonly reported dose-related side effects are: drowsiness dizziness fatigue.
Dr. David Rosenfeld
Dr. David Rosenfeld
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