7 doctors weighed in:
My daughter's doctor is 99% sure she has mthfr defect. What can you tell me about it?
7 doctors weighed in

Dr. Cindy Juster
Pediatrics
4 doctors agree
In brief: Depends on which one
Methylene tetrahydrofolate reductase (mthfr) mutations, deficiencies, & other abnormalities are associated with a variety of health issues, including clotting disorders, congenital heart & aorta defects, metabolic disorders, B12 deficiency & autoimmune atrophic gastritis, cleft lip and palate, & miscarriages.
Her doctor can discuss which specific mthfr problem she has and what it can cause.

In brief: Depends on which one
Methylene tetrahydrofolate reductase (mthfr) mutations, deficiencies, & other abnormalities are associated with a variety of health issues, including clotting disorders, congenital heart & aorta defects, metabolic disorders, B12 deficiency & autoimmune atrophic gastritis, cleft lip and palate, & miscarriages.
Her doctor can discuss which specific mthfr problem she has and what it can cause.
Dr. Cindy Juster
Dr. Cindy Juster
Thank
Dr. Su Fairchild
Integrative Medicine
2 doctors agree
In brief: Test
Most labs such as quest and labcorp can do the mthfr test.
Prices can range from $120 to $400. About 1/4 of the population has some kind of methylation defect, so i think it is worth checking.

In brief: Test
Most labs such as quest and labcorp can do the mthfr test.
Prices can range from $120 to $400. About 1/4 of the population has some kind of methylation defect, so i think it is worth checking.
Dr. Su Fairchild
Dr. Su Fairchild
Thank
Dr. Allen Lewis
Pediatrics
1 doctor agrees
In brief: Folic acid chemistry
Homozygous mutation at either the a1298c or c677t location significantly decrease methylation, the process by which genes are regulated, neurotransmitter balance is maintained & consequently mood.
The c677t variant is more easy to support by bypassing mthfr with supplemental 5-methyltetrahydrofolate. The a1298c variant is more complicated because of the way the mutation affects the mthfr protein.

In brief: Folic acid chemistry
Homozygous mutation at either the a1298c or c677t location significantly decrease methylation, the process by which genes are regulated, neurotransmitter balance is maintained & consequently mood.
The c677t variant is more easy to support by bypassing mthfr with supplemental 5-methyltetrahydrofolate. The a1298c variant is more complicated because of the way the mutation affects the mthfr protein.
Dr. Allen Lewis
Dr. Allen Lewis
Thank
Dr. Jill Carnahan
Family Medicine
In brief: MTHFR Gene mutation
If you'd like to do more reading on the health effects of mthfr gene mutation, here's a great article .
.. http://doccarnahan.blogspot.com/2013/10/whats-big-deal-about-methylation-update.html.

In brief: MTHFR Gene mutation
If you'd like to do more reading on the health effects of mthfr gene mutation, here's a great article .
.. http://doccarnahan.blogspot.com/2013/10/whats-big-deal-about-methylation-update.html.
Dr. Jill Carnahan
Dr. Jill Carnahan
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