What is the effect of Ampiclox in first trimester of pregnancy?

Relatively safe. Ampiclox is Ampicillin + cloxacillin. Both of these are fda pregnancy category b. According to drugs.Com: there are no controlled data in human pregnancies; however, there are no literature reports of congenital abnormalities associated with it. Cloxacillin should only be given during pregnancy when need has been clearly established.”.
Safe in pregnancy. Penicillins are considered safe in pregnancy and the combination medication of Ampicillin and cloxacillin are both penicillins. This will not cause birth defects or abortion according the published studies. Penicillins are used in pregnancy to treat infections.