8 doctors weighed in:

Do selective adeno-adenergic blockers (prazosin, terazosin, doxazosin, trimazosin) protect  from acute cocaine-induced vasoconstrictive damage?

8 doctors weighed in
Dr. Edward Neilsen
Family Medicine
4 doctors agree

In brief: Some

Cocaine causes it's effect by preventing the reuptake of monamine (epinephrine, etc) and causes these neurotransmitters to continue exciting the a1 receptor. The meds listed block alpha-1 receptors, so theoretically will blunt the effects of Cocaine on some vessels, but focus mostly (esp.
Tamsulosin) on a specific sub-type (alpha-1a) that is mostly in the bladder, not in the vessels.

In brief: Some

Cocaine causes it's effect by preventing the reuptake of monamine (epinephrine, etc) and causes these neurotransmitters to continue exciting the a1 receptor. The meds listed block alpha-1 receptors, so theoretically will blunt the effects of Cocaine on some vessels, but focus mostly (esp.
Tamsulosin) on a specific sub-type (alpha-1a) that is mostly in the bladder, not in the vessels.
Dr. Edward Neilsen
Dr. Edward Neilsen
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Dr. Alan Wartenberg
Addiction Medicine
2 doctors agree

In brief: Probably not

I am unaware of any studies of this, but the mechanism by which Cocaine causes vasoconstriction is very different than the mechanism by which these drugs cause vasodilation.

In brief: Probably not

I am unaware of any studies of this, but the mechanism by which Cocaine causes vasoconstriction is very different than the mechanism by which these drugs cause vasodilation.
Dr. Alan Wartenberg
Dr. Alan Wartenberg
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