7 doctors weighed in:
How does tenofovir cause renal failure ?
7 doctors weighed in

Dr. Edward Neilsen
Family Medicine
3 doctors agree
In brief: Accumulation
Tenofovir, or viread, (tenofovir) is a powerful antiviral medication for hiv.
It has, in rare cases, been thought to contribute to renal failure. The thought is that the drug and metabolites of the drug accumulate in the tubule of the kidneys, causing damage to the filtering system. However, some studies have shown that tenovir is no more toxic than other antivirals.

In brief: Accumulation
Tenofovir, or viread, (tenofovir) is a powerful antiviral medication for hiv.
It has, in rare cases, been thought to contribute to renal failure. The thought is that the drug and metabolites of the drug accumulate in the tubule of the kidneys, causing damage to the filtering system. However, some studies have shown that tenovir is no more toxic than other antivirals.
Dr. Edward Neilsen
Dr. Edward Neilsen
Thank
Dr. Fred McCurdy
Pediatrics - Nephrology & Dialysis
2 doctors agree
In brief: Accumulation
Tenofovir exits the body only through the kidneys and if the levels of drug get too high, the part of the kidney called the proximal tubule begins to accumulate the drug.
Result - acute renal failure due to death of the proximal tubule cells. Other things can also happen when the proximal tubules are injured, but there's not enough space to elaborate.

In brief: Accumulation
Tenofovir exits the body only through the kidneys and if the levels of drug get too high, the part of the kidney called the proximal tubule begins to accumulate the drug.
Result - acute renal failure due to death of the proximal tubule cells. Other things can also happen when the proximal tubules are injured, but there's not enough space to elaborate.
Dr. Fred McCurdy
Dr. Fred McCurdy
Thank
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