What works best for chronic fatigue?

Variable. There are many different causes and reasons for chronic fatigue ranging from hypothyroidism to anemia to cardiac disease or emotional conditions. Therefore, there is no set answer to this question. The cause of the fatigue needs to be investigated with your physician.
Daily excersise. Excersise daily proven to be the best therapy.
Chronic fatigue. Depends completely on the cause or causes of the fatigue. If you are chronically fatigued, you should discuss this with your primary care doctor to determine the cause and then you can have proper treatment. Meanwhile make sure you are living a healthy life style.
Find & Rx cause. Chronic fatigue syndrome is a multifactorial consequence of hormonal, immune system and nervous system dysfunction resulting from genetic predispositions and dietary and environmental insults. These factors impair the patient's ability to produce energy and they end up chronically fatigued. There are numerous internal & external stressors that can contribute to this syndrome. Find & rx.
Find a holistic MD. Treating chronic fatigue requires investigation, commitment by the patient, and of course, some patience. Cfs typically involves underactive thyroid and adrenal glands, vitamin deficiencies, food allergies/sensitivities, immune support, stress reduction, and sleep. This is assuming that anemia and sleep apnea and infectious diseases have been ruled out.