8 doctors weighed in:
I have all the symptoms for lupus or ra, but tests came back negative. Can I still have either?
8 doctors weighed in

Dr. Angus Worthing
Internal Medicine
4 doctors agree
In brief: RA maybe; lupus no
Blood tests for RA are negative in up to 30 percent of cases.
The screening blood test for lupus is negative only rarely.

In brief: RA maybe; lupus no
Blood tests for RA are negative in up to 30 percent of cases.
The screening blood test for lupus is negative only rarely.
Dr. Angus Worthing
Dr. Angus Worthing
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Dr. Kenneth Cheng
Family Medicine
1 doctor agrees
In brief: Yes
Symptoms of lupus and rheumatoid arthritis can have similarities as well as differences.
Nonetheless, it is possible to have either despite having a negative RA or lupus test. No medical test is ever 100% accurate every time as there are false positives and false negatives. In medicine, we have a saying, "we are treating patients, not lab results." however, keep exploring other poss diagnoses.

In brief: Yes
Symptoms of lupus and rheumatoid arthritis can have similarities as well as differences.
Nonetheless, it is possible to have either despite having a negative RA or lupus test. No medical test is ever 100% accurate every time as there are false positives and false negatives. In medicine, we have a saying, "we are treating patients, not lab results." however, keep exploring other poss diagnoses.
Dr. Kenneth Cheng
Dr. Kenneth Cheng
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Dr. Pierre Moeser
Internal Medicine - Rheumatology
In brief: Yes
A significant number of patients with rheumatoid arthritis have negative blood tests but still have the disease.
The history, physical examination, x-rays, and other blood tests may verify the disease. Lupus with negative blood tests is rare.

In brief: Yes
A significant number of patients with rheumatoid arthritis have negative blood tests but still have the disease.
The history, physical examination, x-rays, and other blood tests may verify the disease. Lupus with negative blood tests is rare.
Dr. Pierre Moeser
Dr. Pierre Moeser
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Dr. Michael Laccheo
Internal Medicine - Rheumatology
In brief: Yes
Yes, but the likelihood of that depends on what tests were ordered.
Both sle and RA are clinical diagnoses being made based on multiple factors including history, examination and lab work. Around 15% of patients will have rheumatoid arthritis without a positive rheumatoid factor or anti-ccp antibody. It is much less likely for someone to have sle if their ANA and other serologies are negative.

In brief: Yes
Yes, but the likelihood of that depends on what tests were ordered.
Both sle and RA are clinical diagnoses being made based on multiple factors including history, examination and lab work. Around 15% of patients will have rheumatoid arthritis without a positive rheumatoid factor or anti-ccp antibody. It is much less likely for someone to have sle if their ANA and other serologies are negative.
Dr. Michael Laccheo
Dr. Michael Laccheo
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