My mother has neuropathy in both feet and pain that shoots up her legs at night, very painful, has tried accupunture physical therapy and nothing help?

Neuropathy. There are several causes of this type of pain. Your mother should be examined for the cause of the pain and then proper treatment can be given. Treating the cause is the best way to find relief of the pain.
B vitamins. Neuropathy can be very painful but b vitamins can be beneficial in alleviating the pain. You may want to see a neurologist to get further help as far as determining the cause; if you have not done so already.