Difference between idiopathic thrombocytopenia purpura and thrombotic thrombocytopenia purpura?

The are completely. Different. Itp is the autoimmune destruction of platelets and is managed with immunosuppression - the first line is usually prednisone. Ttp is the microvascular consumption of platelets (small clots). This can be associated with anemia, renal failure, ha and fever. It is a medical emergency and is managed with plasma exchange.
Its Complicated. Itp; history of viral illness, associated with lymphoma, cll, hiv, connective tissue diseases (no splenomegaly or megakaryocytes) chronic and insidious course in adults, ttp (pneumonic: fat registered nurse) fever, anemia, thrombocytopenia, renal involvement, neurologic involvement itp treatment : steroids / Prednisone / ivig / Rhogam with possible splenectomy ttp ....... Plasmapheresis.

Related Questions

How come I have thrombotic thrombocytopenia purpura, but nobody else in the family has it?

Not hereditary. Ttp of thrombotic thrombocytopenic purpura is not a hereditary disease. Most of them is idiopathic i.e. Unknown etiology in about 37 percent. Others are related to drugs , autoimmune disease, infection such as hiv, endothelial injury, stem cell transplant etc. Read more...

Most common symptoms of thrombotic thrombocytopenia purpura?

TTP. Most common symptoms would be headache and fatigue- however one can be presented with different kind of neurological problems- including confusion, shaking/involuntary movement etc that is caused by the ttp. The most common sign -off course is low platelet. Read more...
Range of symptoms. Ttp can involve many different organs. One can have renal dysfunction, fever, altered mental status, low platelet counts and hemolytic anemia. These signs can lead to symptoms of bleeding, bruising, petechiae, confusion, anemia, fatigue, and possible jaundice among other things. Read more...

Do people with thrombotic thrombocytopenia purpura have a lot of pain?

No usually. People with itp usually bleed more frequently following gently trauma, like a bump. In more severe forms, itp can be associated with gastric hemmorrages, which are painful, but this is rare. Read more...
TTP. Ttp or thrombotic thrombocytopenic purpura can be manifested with seizure, coma, renal failure, cardiac hemmorhage/bleeding, sudden cardiac arrest, myocardial infarction, other thrombotic events such as DVT etc. They will need to get treatment as soon as possible to survive. The pain can happen and usually is related thrombotic events -such as blood clots in deep vein, or heart attack. Read more...

What is the disease? Thrombotic thrombocytopenia purpura?

Abnormal platelet. Function due to deficiency of a metaloproteinase. Deficiency, usually acquired, of an enzyme that breaks down large multimers of von willebrand factor causes overactivation of platelets leading to intravascular microthrombi that affect the functions of the kidneys, brain, lungs and other organs. It can be treated by transfusing normal donor plasma. Read more...

What is the definition or description of: thrombotic thrombocytopenia purpura?

TTP is a serious. Medical condition in which the platelets form clots within the small blood vessels throughout the body. Patients usually come to attention due to low HGB or platelets, but also may have fever, kidney insufficiency, seveer headache, and even seizures and stroke. This is an absolute medical emergency. Read more...

What is idiopathic thrombocytopenia purpura?

Autoimmune disease. Idiopathic thrombocytopenic purpura is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. Persons with the disease have too few platelets in the blood. Check this site: http://www.Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0001562/. Read more...
ITP is just what... It sounds like. It is characterized by bleeding, bruising (purpura) and petechiae that develop because of a low PLT count (aka thrombocytopenia), and where the specific trigger for thrombocytopenia is not known (idiopathic). We do know that in itp, the pt makes antibodies to auto-antigens found on the PLT surface (often pla-1) which mark them for destruction. This makes the PLT count low. Read more...

What is the treatment for idiopathic thrombocytopenia purpura?

Steroids & surgery. Many cases of itp resolve with supportive care and corticosteroid treatment. In resistant cases, spleen, the site of platelet destruction, may be removed. Read more...
Many options. If you have no symptoms, waiting can sometimes be an option. Ivig, winrho (if you are rh(+)) or steroids (once you have ruled out malignancy as the cause for low platelets) can be used. If these are unsuccessful, potent immunosuppressives can be considered such as vincristine or rituximab. Splenectomy can also be considered for someone who is refractory to medical intervention. Read more...