Dose dependent. Excedrin is a combination of Acetaminophen (tylenol) Aspirin and caffeine. Acetaminophen is recommended to mot exceed 300mg/day. Aspirin can cause ulcers and bleeding. Caffeine is a stimulant. People who are taking "blood thinners" should discuss the use of Aspirin with their physicians. If you are taking this or any pain product for long term, you should discuss this with your physician.
What are the long term effects of taking excedrin? Approximately 4 per/day now for approximately 4 years
See below. While Aspirin is generally safe its use can lead to stomach irritation and bleeding. In addition easy buising is seen.