About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance. Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www.Cancer.Gov/cancertopics/factsheet/risk/brca.
50% chance . Each child of a father carrying a brca mutation has a 50% chance of having the same mutated gene. If a daughter has the brca1 mutation, she will have a higher chance of developing breast and ovarian cancer at an early age. Any child of a parent with a brca mutation should have genetic counseling and testing before childbearing age.
50% Each child of a brca mutation carrier has a 50/50 chance of getting the mutation regardless of gender. We usually test them for only that particular mutation (single site analysis) which is cheaper. Word of warning: two individuals with two different mutations can be married and then each child can inherit none, one, or both. We need to know the family history of both sides of the family.

Related Questions

If two members of my immediate family developed breast cancer, should I get tested for the brca gene?

Possibly. It's always better to test the family members who have breast cancer if possible. If they are first degree relatives (mother, daughter or sister) and one was under age 50 at diagnosis, you might meet criteria for brca testing. It's best to meet with a genetic counselor who can help guide you and your family so the correct people are tested. There are non-brca mutations as well. Read more...
Maybe. It would be best if the family member with the breast cancer gets brca testing. If it was positive then you definitely need to be tested too. If she was negative, then the cancer was probably not related to brca gene mutations and you won't need to be tested. You still will be at higher for breast ca. If your family member was not willing or able to test, then you may want to be tested. Read more...
Depends. It would depend on your heritage and also at what age were your immediate family members diagnosed. I would seek the advice of a genetic counselor. Read more...
Absolutely. Women w/ 2+ immediate family members w/ a hx of breast/ovarian CA at 50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing. Read more...

Can all breast cancer patients carry the brca genes?

No! Many patients with breast cancer have no genetic predisposition or risk for breast cancer. However, there are several genetic markers which increase the risk of developing breast cancer over a person's lifetime. Read more...
Yes and no. We all have the brca genes in our dna. God (or evolution, your choice) put it there with the purpose of repairing damaged dna, destroying dna that can't be repaired, and other things. When it's mutated (changed) in certain places, it does not work and leads to the development of cancer. Only a small number of breast cancer patients inherit such deleterious or "bad" mutations. Read more...
Yes, and no. We all have the genes named brca, but we don't all have mutations in those genes. It's the brca mutations that increase the risk for breast cancer. It turns out that 85% of breast cancers have nothing to do with the brca gene. So most patients with breast cancer do not have a brca1 or brca2 mutation. I hope that answers your question! Read more...

What are the statistics of the brca/breast cancer gene?

Low incidence. Approximately 1 in 40 ashkenazi jewish women have a brca mutation. It also is seen in other isolated populations. A brca1 mutation can be inherited from a mother or father and is associated with up to a 80% lifetime risk of breast cancer and a 40 % risk of ovarian cancer options include increased surveillance chemo prevention or risk reduction surgery. Read more...
Family history. It depends on your family history. If you do not have cancer yourself, you may still carry the gene. If a parent, sibling, grandparent or aunt/uncle has had ovarian cancer, breast cancer before age 45, or if any male relatives have had breast cancer, or if anyone in your family is known to carry a brca mutation, you may be at risk. Ask your doctor if genetic counseling is recommended. Read more...
Risky! Women w/ 2+ immediate family members w/ a hx of breast/ovarian CA at 50% chance of developing breast cancer. If you have it, get screened with CA-125 blood test, ultrasound, mammogram/MRI, usually starting at age 30. Surgery after childbearing. Read more...

When I have my daughter tested for brca gene? My husband's sister was diagnosed with stage 3 breast cancer.  no other history of b.C. In our families.

Good idea. Always better to know than remain in ignorance. She can always get bc advice if brca gene testing ispositive. Read more...
Not yet. I am sorry to hear about your sister-in-law. In general, when we are concerned about the hereditary form of breast cancer, we test the affected person first. If they don't harbor the gene, there is no need to test anyone else. Keep in mind that 85-90% of all breast cancer cases are not hereditary. Even if your sister-in-law has the gene, your husband has a 50% chance as well, and your daughter 25%. Read more...
Not just yet. A single person with breast cancer in the family is not generally considered a reason for brca testing. A history of multiple indviduals with breast or ovarian cancer or both is usually required. Onset of cancers at an early age and breast cancer in male family members are also important. If your doc feels there is risk you and your daughter should receive genetic counciling before tests are done. Read more...
Not now. If your sister in law had cancer before age 45 or had a triple negative cancer before age 60, she fits nccn criteria for brca testing even without family history. She needs to test first and if positive, your husband should test and if he is positive, then you test your girl. Cancer can jump an individual but the gene cannot. Hope all goes well with all in the family. Read more...

How many relatives need to have had breastcancer before you should get genetic testing for the BRCA genes? My mother contracted breast cancer, I am 40

Other factors must . be considered. If your mom had a harmful BRCA1 or BRCA2 mutation, breast cancer diagnosed before age 50, cancer in both breasts, both breast and ovarian cancers, multiple breast cancers or your ethnicity is Ashkenazi Jewish, talk to your GYN about genetic counseling to evaluate your potential risk. Read more...
Usually 2. With some exceptions, the number is two first-degree relatives (mom/sisters), before screening for BRCA. Exceptions include if there is a history of ovarian cancer, pre-menopausal breast cancer (age . Read more...
See genetics. Most breast cancer is NOT due to an inherited risk, but rather occurs by chance. Family history that suggests an inherited risk, such as changes in the BRCA1 gene or BRCA2 gene, include multiple relatives with cancer over more than one generation and younger ages of onset. If you are concerned about an inherited risk, see a geneticist who can assess your family history. Read more...

My mother had breast cancer at 54 and her cousin was diagnosed at 45. Is this likely caused by the brca gene? My insurance won't pay for it.

Possible. It is hard to say without a full family history but your relatives did have cancer at a young age. Per nccn guidelines, both are candidates for testing (assuming they are still alive). They would be the best subjects for testing and then you may or may not need to. If they can't or won't, i advise you talk to your doc to see if a genetic counselor can see you and decide on the proper testing. Read more...
BRCA. Probably not. The patient to be tested is the cousin due to age at diagnosis. You do not qualify because you're risk of having the gene is so low. That's a good thing! Read more...
Nope! If you don't have breast or ovarian cancer yourself, then you need a family history of breast cancer in two close relatives (parent, sibling, aunt, granparent, niece) on the same side of the family, or one close relative diagnosed with breast cancer before age 45. Your mother's cousin doesn't qualify as a close relative. Ask to see a genetic counselor to better define your risk. Read more...

If negative for brca gene, yet father had prostate cancer, is his daughter still at risk for breast cancer? I heard they were linked.

BRCA gene links. A family history of breast ovarian or colon cancer can predispose future genetic progeny if the BRCA is positive. I am unaware of a negative BRCA link to prostate cancer in males producing breast cancer in the female progeny. Read more...
Not elevated risk. In families who DO have a BRCA mutation, the breast and prostate cancers can be linked. However both are very common cancers, so they can be seen within families even if BRCA negative. The average lifetime risk of breast cancer for any given woman is 12.5%. You can do a search for the Gail Risk Model to get a little better idea of your own personal risk. Read more...