For one week I have had a headache, fatigue, hoarseness and itchy throat. I've taken Advil (ibuprofen) and rested but no improvement. What could this be.

See below. Any fever/chills? Muscle aches? Sinus pain/ pressure? Post-nasal drainage? Cough? Ear pain? What part of head aches? Might be upper respiratory infection (usually viral, but possible bacterial), influenza (if body aches). Theraflu or advil (ibuprofen) cold & sinus may give better relief. Drink plenty of fluids. Gargle with warm salt water. See doc if no improvement in couple days.