Might I still have celiac if the blood and gene tests were positive, but the biopsy was negative?

Yes. Celiac disease is a patchy disease. Sometimes biopsies obtained may be from normal areas.
Yes. The genetic tests for 2 genes which predispose to Celiac disease aren't very useful, as 30% of Caucasian Americans have at least 1.The most sensitive and specific tests are for the autoantibodies, tTG and deamidated gliadin. If they are positive, a small bowel jejunal biopsy is indicated. Villous atrophy is diagnostic. However, a person may have the disorder and not have a positive biopsy.

Related Questions

Can I have celiac if the blood and gene tests were positive, but biopsy was negative?

Yes, you can. Celiac disease often presents in the small bowel as "patchy" so biopsies of only one area may not be representative. Also, if you have celiac disease but eliminated gluten long enough for classic villous blunting changes in the small bowel to have resolved, then biopsies will look normal & the disease may be missed. Talk to your doctor about definitive diagnostic criteria for your piece-of-mind. Read more...