8 doctors weighed in:
Might I still have celiac if the blood and gene tests were positive, but the biopsy was negative?
8 doctors weighed in

Dr. Vijay Laxmi Misra
Internal Medicine
4 doctors agree
In brief: Yes
Celiac disease is a patchy disease.
Sometimes biopsies obtained may be from normal areas.

In brief: Yes
Celiac disease is a patchy disease.
Sometimes biopsies obtained may be from normal areas.
Dr. Vijay Laxmi Misra
Dr. Vijay Laxmi Misra
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Dr. Jack Mutnick
Internal Medicine - Allergy & Immunology
1 doctor agrees
In brief: Yes
Yes. Keep a gluten-free diet.

In brief: Yes
Yes. Keep a gluten-free diet.
Dr. Jack Mutnick
Dr. Jack Mutnick
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1 comment
Dr. Richard Roberts
prior to a gluten-free diet, obtain antibody studies specific for celiac disease
Dr. Richard Roberts
Clinical Genetics
In brief: Yes
The genetic tests for 2 genes which predispose to Celiac disease aren't very useful, as 30% of Caucasian Americans have at least 1.
The most sensitive and specific tests are for the autoantibodies, tTG and deamidated gliadin. If they are positive, a small bowel jejunal biopsy is indicated. Villous atrophy is diagnostic. However, a person may have the disorder and not have a positive biopsy.

In brief: Yes
The genetic tests for 2 genes which predispose to Celiac disease aren't very useful, as 30% of Caucasian Americans have at least 1.
The most sensitive and specific tests are for the autoantibodies, tTG and deamidated gliadin. If they are positive, a small bowel jejunal biopsy is indicated. Villous atrophy is diagnostic. However, a person may have the disorder and not have a positive biopsy.
Dr. Richard Roberts
Dr. Richard Roberts
Thank
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