Can very high positive ANA alone possibly make one feel tired and just not well when other labs are currently normal in person with lupus/sjogren. How?
No. A high titer ANA is not a good correlate of disease activity. Talk to your provider. Only actual clinical problems or specific antibody titers correlate with disease activity. I have many patients with high titer anas and no systemic lupus erythematosis or sjogren's disease activity whatsoever.