Why do you ask? I wouldn't do it. They're endearing. Many people like them. If you try freckle removers, you risk disfiguring yourself.
Sun protection. You won't be able to permanently remove freckles with any home remedies or over the counter medications. Your best bet is use good sun protection including use of sunscreen every day, hats, sunglasses, sun protective clothing. Your doctor may prescribe a topical cream such as hydroquinone which can also help, but nothing is as important as protecting your skin.