4 doctors weighed in:
Can vicodin abuse cause the brain's chemistry to be altered in a way that causes depression?
4 doctors weighed in

Dr. Stephen Perret
Pediatrics - Psychiatry
In brief: Possibly
Vicodin is an painkiller that works on the brain through the "opiate" receptor. It certainly affects brain chemistry.
Many common medications and chemicals have been found or are already known to potentially contribute to depression including pain killers, antibiotics, and many others.

In brief: Possibly
Vicodin is an painkiller that works on the brain through the "opiate" receptor. It certainly affects brain chemistry.
Many common medications and chemicals have been found or are already known to potentially contribute to depression including pain killers, antibiotics, and many others.
Dr. Stephen Perret
Dr. Stephen Perret
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Dr. Donald Hazlett
Psychiatry
In brief: Yes it can.
All opioids are depressants and can cause depression directly especially when used chronically.
Withdrawal can often lead to depression when stopping opioids, again especially in long term use. All narcotics have that potential. Some people seem more sensitive to that resulting depression. One caveat - bipolar and ptsd people often are depressed and tend to seek out opioids to ease emotional pain.

In brief: Yes it can.
All opioids are depressants and can cause depression directly especially when used chronically.
Withdrawal can often lead to depression when stopping opioids, again especially in long term use. All narcotics have that potential. Some people seem more sensitive to that resulting depression. One caveat - bipolar and ptsd people often are depressed and tend to seek out opioids to ease emotional pain.
Dr. Donald Hazlett
Dr. Donald Hazlett
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2 comments
Dr. Stuart Wasser
actually-the immediate effects of opioids is that of an anti-depressant. But it is through rebound during withdrawawal, especially when there is significant tolerance,- that problems with depression emerge
Dr. Kevin Nasky
Opioids do not cause depression. Their immediate affect on mood, in fact, is euphoric. Only in withdrawal do people usually experience depressive symptoms.
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