4 doctors weighed in:

Is long-term oxycodone (opana) use safer than long-term vicodin or norco (hydrocodone and acetaminophen) use, since the former contains no acetaminophen which harms the liver?

4 doctors weighed in
Dr. Dennis Yun
Anesthesiology
2 doctors agree

In brief: Possibly

Most medications are processed through your liver. Normally, a healthy liver will easily process and eliminate acetaminophen.
However, if the liver is abnormal or exposed to excess amounts of acetaminophen, then severe harm could result. Remember that all opioids (opana, vicodin, etc) must be taken carefully under your physician's guidance.

In brief: Possibly

Most medications are processed through your liver. Normally, a healthy liver will easily process and eliminate acetaminophen.
However, if the liver is abnormal or exposed to excess amounts of acetaminophen, then severe harm could result. Remember that all opioids (opana, vicodin, etc) must be taken carefully under your physician's guidance.
Dr. Dennis Yun
Dr. Dennis Yun
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Dr. Alan Wartenberg
Addiction Medicine
2 doctors agree

In brief: Depends

Actually, Opana is oxymorphone, rather than oxycodone.
Both come in preparations that have no tylenol (acetaminophen) in them, as do many other opioids (fentanyl, morphine). There is talk of a monotherapy extended release hydrocodone as well. If tylenol (acetaminophen) use is under 4 grams per day (short-term - 1-2 months) and under 2 grams per day for longer, there is little evidence of harm to liver or kidneys.

In brief: Depends

Actually, Opana is oxymorphone, rather than oxycodone.
Both come in preparations that have no tylenol (acetaminophen) in them, as do many other opioids (fentanyl, morphine). There is talk of a monotherapy extended release hydrocodone as well. If tylenol (acetaminophen) use is under 4 grams per day (short-term - 1-2 months) and under 2 grams per day for longer, there is little evidence of harm to liver or kidneys.
Dr. Alan Wartenberg
Dr. Alan Wartenberg
Thank
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