Is long-term oxycodone (opana) use safer than long-term vicodin or norco (hydrocodone and acetaminophen) use, since the former contains no acetaminophen which harms the liver?

Possibly. Most medications are processed through your liver. Normally, a healthy liver will easily process and eliminate acetaminophen. However, if the liver is abnormal or exposed to excess amounts of acetaminophen, then severe harm could result. Remember that all opioids (opana, vicodin, etc) must be taken carefully under your physician's guidance.
Depends . Actually, Opana is oxymorphone, rather than oxycodone. Both come in preparations that have no tylenol (acetaminophen) in them, as do many other opioids (fentanyl, morphine). There is talk of a monotherapy extended release hydrocodone as well. If tylenol (acetaminophen) use is under 4 grams per day (short-term - 1-2 months) and under 2 grams per day for longer, there is little evidence of harm to liver or kidneys.

Related Questions

I've been taking norco (hydrocodone and acetaminophen) 10/325 for about 5 years 6 in a day I feel twiching in my liver area and slight pain in liver area should I be concerned?

Norco (hydrocodone and acetaminophen) and abdominal. Why are you on Norco (hydrocodone and acetaminophen)? and for so long? Is well known to be hepatotoxic, and may induce cirrhosis of the liver. You need a series of blood tests to check your liver enzymes and see if your liver has been compromised. Would you like to make an appointment with me and we go over all issues. Special Risk Patients: As with any narcotic analgesic agent, Norco (hydrocodone and acetaminophen)® should be used with caution in elderly or debilitated patients and those with severe impairment of hepatic or renal function, hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture. The usual precautions should be observed and the possibility of respiratory depression should be kept in mind. Read more...

I have chronic interstitial cystitis. Tried several meds with limited success. Is it normal to be on a pain medication such as norco (hydrocodone and acetaminophen) long term?

Most of the time . Other treatments can be found for ic. Consult a urologist or urogynecologist. Read more...
I wouldn't. I'd try Gabapentin or Lyrica (pregabalin) plus an antidepressant. I'd consider the implantable stimulators. I have seen patients have pain or frequency disappear. Urologist or pain physician would put them in. Norco long term will make pain worse and doesn't work for neuropathic pain anyway. Read more...