Depends on Particles
Cardiovascular (cvd) risk is related to LDL
(ldl-p) and HDL
(hdl-p) particle number. Because cholesterol in LDL and HDL particles is highly variable, ldl-c and hdl-c levels often disagree with ldl-p and hdl-p.
When cholesterol and particle number disagree cvd risk tracks with ldl-p and hdl-p, not ldl-c or hdl-c. For high risk patients ldl-p goal is < 1000 (option < 800), otherwise goal is < 1300.