3 doctors weighed in:

Does the use of imiquimod increase the risk of HIV transmission? If so, is it b/c of irritation or b/c of enhanced immune response?

3 doctors weighed in
Dr. Dominic Riganotti
Internal Medicine - Infectious Disease
1 doctor agrees

In brief: No hard data

Interesting question.
Imiquimod is externally used for condyloma (warts) as you already know. There have been no studies showing what you ask. Now...Thinking logically...Anything that causes irritation or a break in the skin surface should put one at higher risk to acquire hiv..Especially when its associated with a mucous membrane. So i would say yes...But there is no data to support this.

In brief: No hard data

Interesting question.
Imiquimod is externally used for condyloma (warts) as you already know. There have been no studies showing what you ask. Now...Thinking logically...Anything that causes irritation or a break in the skin surface should put one at higher risk to acquire hiv..Especially when its associated with a mucous membrane. So i would say yes...But there is no data to support this.
Dr. Dominic Riganotti
Dr. Dominic Riganotti
Thank
Dr. Ricky Hsu
Internal Medicine

In brief: Yes (macaque study)

Imiquimod (a tlr receptor agonist) may theoretically decrease HIV transmission by increasing ifn Alpha & beta at the affected area.
However, it also results in a pro-inflammatory response that can increase HIV transmission via skin irritation. This question was tested in macaques showing that topical application actually led to higher siv viremia in monkeys receiving Imiquimod & no protection.

In brief: Yes (macaque study)

Imiquimod (a tlr receptor agonist) may theoretically decrease HIV transmission by increasing ifn Alpha & beta at the affected area.
However, it also results in a pro-inflammatory response that can increase HIV transmission via skin irritation. This question was tested in macaques showing that topical application actually led to higher siv viremia in monkeys receiving Imiquimod & no protection.
Dr. Ricky Hsu
Dr. Ricky Hsu
Thank
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