Does hydrocephalus cause major weight loss?

It can. Hydrocephalus is a neurologic condition that refers to a collection of cerebrospinal fluid (CSF) that accumulates in the cavities (ventricles) in the brain. It can cause weight loss if it is associated with the known symptoms of nausea with or without vomiting. Also having headaches and being fatigues tend to diminish ones caloric intake which can affect weight. I hope this helps.