Should a unilateral nasal polyp be biopsied prior to surgery? Also, should any other treatments be explored prior to just removing it?

Good question. The concern for unilateral polyps is that it might be neoplastic process. Thus at the very least a biopsy is recommended (especially if no surgery is planned). But most surgeons will go ahead and schedule surgery, since the patients are usually pretty symptomatic in the first place. If surgery is not an option, temporary relief can be gained from oral or topical steroid therapy after the biopsy.