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Average time takes for methadone to take effect?

1 doctor weighed in
Dr. Alan Wartenberg
Addiction Medicine

In brief: 2-4 hours

Methadone is not a very good acute pain drug, in that measurable levels do not really take hold until at least an hour, and rarely peak prior to 2 hours, with 3 hours about the mean.
Depends on whether it is being used for pain, in which case relatively smaller doses are used every 4-8 hours (average 4x/d) or for treatment of opioid addiction, when gradually larger doses are given once a day.

In brief: 2-4 hours

Methadone is not a very good acute pain drug, in that measurable levels do not really take hold until at least an hour, and rarely peak prior to 2 hours, with 3 hours about the mean.
Depends on whether it is being used for pain, in which case relatively smaller doses are used every 4-8 hours (average 4x/d) or for treatment of opioid addiction, when gradually larger doses are given once a day.
Dr. Alan Wartenberg
Dr. Alan Wartenberg
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