Any idea what can cause uper leg pain when I try to put some presure the or try bend knees did a lot of exams MRI while spine brain blood work clear?

Hip? Next thing to check is hip and proximal femur in you age group hip problems would be labral tear avn or pauciarticular RA or dysplasia and early DJD esp if you limp as well, limp spiine clear think hipsee orthopedist.